protein

TNK2PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TNK2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	TNK2PROTEIN
Full Name	TNK2/ACK1
Chromosome	3p21.3.
Protein Type	Protein
Function	is a non-receptor tyrosine kinase that plays important roles in cell signaling, cytoskeletal organization, and neuronal function.
Primary Expression	both neurons and glia, with highest expression in regions associated with learning and memory including the [hippocampus](/brain-
UniProt ID	Search UniProt
GeneCards	TNK2PROTEIN
Human Protein Atlas	TNK2PROTEIN
Aim-100	Highly selective ACK1 inhibitor, showed neuroprotective effects in preclinical models
Dasatinib	FDA-approved tyrosine kinase inhibitor with ACK1 activity
KX-01	Novel ACK1/TNK2 inhibitor in development
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TNK2PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TNK2/ACK1 Protein

protein · 623 words

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Pathway Diagram

graph TD
    TNK2PROTEIN["TNK2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TNK2PROTEIN -->|"implicated_in"| neurodegeneration
    style TNK2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TNK2PROTEIN in their description or question text

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