gene

TNKS2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TNKS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for TNKS2 Gene

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🧬 Gene Info

Gene Symbol	TNKS2
Full Name	Tankyrase 2
Aliases	TNKS2/PARP5B
Chromosome	8p23.1
Function	This function overlaps with and is partially redundant to TNKS1.
Primary Expression	many tissues including the brain, where it plays roles in neuronal development and function
Subcellular Localization	telomeres and contribute to telomere length regulation. While TNKS1 is the primary tankyrase at telomeres, TNKS2 can par
Molecular Weight	139 kDa
Amino Acids	1206 aa
Exons	24
Pathways	Wnt signaling, Wnt Signaling, Wnt
UniProt ID	Q9H2K2
NCBI Gene ID	56651
Ensembl ID	ENSG00000137101
OMIM	607341
GeneCards	TNKS2
Human Protein Atlas	TNKS2
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNKS2 — AlphaFold Q9H2K2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TNKS2 Gene

gene · 638 words

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TNKS2 Protein

protein · 1534 words

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Pathway Diagram

graph TD
    TNKS2["TNKS2"]
    neurodegeneration["neurodegeneration"]
    TNKS2 -->|"implicated_in"| neurodegeneration
    style TNKS2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TNKS2 in their description or question text

No additional research found