Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2 and C3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SOX10 and DLX1/2 | co_associated_with | gene | 0.40 |
| SYN1, SLC1A2, and CX3CR1 | co_associated_with | gene | 0.40 |
| EIF2AK3 (PERK) and EIF2B complex | co_associated_with | gene | 0.40 |
| APOE | co_associated_with | gene | 0.40 |
| BMP4 and BMPR1A | co_associated_with | gene | 0.40 |
| PARP1 and XRCC1 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial TREM2-Complement Axis Modulation | 0.527 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213] | Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei | Neuron | 2026 | 0 |
| The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436] | Gopalakrishna PK, Che Mohd Nassir CMN, A | Cellular and molecular neurobi | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclini [PMID:36180898] | Faridar A, Vasquez M, Thome AD, Yin Z, X | Acta neuropathologica communic | 2022 | 0 |
| Intersection of pathological tau and microglia at the synapse. [PMID:31277708] | ["Vogels Thomas", "Murgoci Adriana-Natal | Acta neuropathologica communic | 2019 | 0 |