Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2/TYROBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2 Deficiency Drives Microglial Senescence via Lipid Meta | 0.800 | neurodegeneration | What molecular mechanisms drive microgli |
| Anti-inflammatory microglial reprogramming via cystatin-C/TR | 0.640 | neurodegeneration | Does the cancer-cystatin-C-TREM2 pathway |
| TREM2-Dependent Senescent Microglia Disrupt Astrocyte Commun | 0.600 | neurodegeneration | Gene expression changes in aging mouse b |
| Disease-Associated Microglia (DAM) Program Drives IBA1 Downr | 0.571 | neuroinflammation | What causes IBA1 low/negative microglia |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells [PMID:41674808] | Acharya A, Ambikan AT, Neogi U, Lamberty | Res Sq | 2026 | 0 |
| Siah2 is a lipid-mediated metabolic sensor in adipose tissue macrophage. [PMID:41690475] | Dang TN, Ghosh B, Panta PR, Taylor JM, K | J Lipid Res | 2026 | 0 |
| Apolipoprotein E dysfunction in Alzheimer's disease: a study on miRNA regulation [PMID:39744521] | ["Wijesinghe Printha", "Li Hao Ran", "Ai | Frontiers in aging neuroscienc | 2024 | 0 |
| Trem2-deficiency aggravates and accelerates age-related myelin degeneration. [PMID:39300502] | ["McCray Tyler J", "Bedford Logan M", "B | Acta neuropathologica communic | 2024 | 0 |
| CD300f immune receptor contributes to healthy aging by regulating inflammaging, [PMID:37864797] | Evans F, Alí-Ruiz D, Rego N, Negro-Demon | Cell reports | 2023 | 0 |
| Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk f [PMID:36411364] | Holstege H, Hulsman M, Charbonnier C | Nat Genet | 2022 | 0 |
| The role of innate immune genes in Alzheimer's disease. [PMID:33560670] | Griciuc A, Tanzi RE | Curr Opin Neurol | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TREM2/TYROBP in their description or question text
No additional research found