Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRIM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Tripartite Motif Containing 3 - a brain-specific E3 ubiquitin ligase involved in neuronal development, synaptic function, and protein quality control
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| Gene Symbol | TRIM3 |
| Aliases | Tripartite Motif Containing 3 |
| Chromosome | 19p13.3 |
| Protein Type | Ligase |
| Function | is a brain-specific E3 ubiquitin ligase belonging to the TRIM (Tripartite Motif) family of proteins [1/https://pubmed. |
| Primary Expression | the brain, particularly in the cerebral cortex, hippocampus, and cerebellum, where it localizes |
| Amino Acids | 741 aa |
| Pathways | TRIM3 Interaction |
| Ensembl ID | ENSG00000146833 |
| GeneCards | TRIM3 |
| Human Protein Atlas | TRIM3 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TRIM3["TRIM3"]
neurodegeneration["neurodegeneration"]
TRIM3 -->|"implicated_in"| neurodegeneration
style TRIM3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity