Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRIM63: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TRIM63 |
| Protein Type | Ligase |
| Function | TRIM63 (Tripartite Motif Containing 63), also known as MURF-1 (Muscle-Specific RING Finger Protein 1), is a muscle-specific E3 ubiquitin ligase that plays a critical role in protein degradation pathwa |
| Pathways | mTOR signaling, NF-κB |
| Ensembl ID | ENSG00000146070 |
| GeneCards | TRIM63 |
| Human Protein Atlas | TRIM63 |
| Myosin heavy chain (MyHC) | Structural protein in muscle fibers 2 |
| Troponin I | Regulatory protein in muscle contraction |
| Titin | Large protein responsible for muscle elasticity |
| Nuclear proteins | Involved in gene regulation |
| LC3 interaction | Can bind to autophagy-related proteins 4 |
| Selective autophagy | Targets damaged proteins for autophagic degradation |
| Mitophagy | May influence mitochondrial quality control in muscle |
| Skeletal muscle | Highest expression in fast-twitch (type II) fibers |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TRIM63["TRIM63"]
neurodegeneration["neurodegeneration"]
TRIM63 -->|"implicated_in"| neurodegeneration
style TRIM63 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TRIM63 in their description or question text
No additional research found