gene

TRMU

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TRMU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TRMU (tRNA Mitochondrial Uridine Synthetase) - mitochondrial tRNA modifier essential for translation and associated with mitochondrial diseases including hearing loss and liver failure.

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🧬 Gene Info

Gene Symbol	TRMU
Full Name	tRNA Mitochondrial Uridine Synthetase (MTU1)
Aliases	tRNA Mitochondrial Uridine Synthetase
Chromosome	22q13.33
Protein Type	Enzyme
Function	TRMU encodes a mitochondrial matrix enzyme that catalyzes the 2-thiolation of uridine residues at the wobble position of mitochondrial tRNAs, specifically tRNALys, tRNAGlu, and tRNAGln [1][2].
UniProt ID	Q9BRR4
NCBI Gene ID	55687
Ensembl ID	ENSG00000100412
OMIM	610230
GeneCards	TRMU
Human Protein Atlas	TRMU
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRMU — AlphaFold Q9BRR4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TRMU Gene

gene · 2149 words

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Pathway Diagram

graph TD
    TRMU["TRMU"]
    neurodegeneration["neurodegeneration"]
    TRMU -->|"implicated_in"| neurodegeneration
    style TRMU fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TRMU in their description or question text

No additional research found