Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRPC4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TRPC4 |
| Chromosome | 13q13.3 |
| Protein Type | Channel |
| Function | TRPC4 forms non-selective cation channels that are primarily activated by G-protein-coupled receptor (GPCR) signaling through phospholipase C (PLC). |
| Primary Expression | the brain, particularly in hippocampal neurons, cortical pyramidal cells, and cerebellar granule cells [3](https://pubmed |
| Subcellular Localization | dendritic membranes and contributes to synaptic integration and plasticity [11](https://pubmed.ncbi.nlm.nih.gov/19139269 |
| Ensembl ID | ENSG00000133189 |
| GeneCards | TRPC4 |
| Human Protein Atlas | TRPC4 |
| Gating Mechanism | Activated by diacylglycerol (DAG) and mechanical stretch 2 |
| Expression Pattern | Widely expressed in the brain, particularly in hippocampal neurons, cortical pyramidal cells, and cerebellar granule cells 3 |
| Physiological Roles | Regulation of neuronal excitability, neurotransmitter release, synaptic plasticity, and neuroprotection 4 |
| Interaction Partners | Associates with TRPC5 to form heteromeric channels, interacts with calmodulin and PLC isoforms 5 |
| Epilepsy | Modulation of TRPC4 activity may reduce seizure frequency 13 |
| Anxiety Disorders | Reduced TRPC4 expression associated with anxiety-like behaviors in mouse models 7 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TRPC4["TRPC4"]
neurodegeneration["neurodegeneration"]
TRPC4 -->|"implicated_in"| neurodegeneration
style TRPC4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||