Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRPC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TRPC5 |
| Chromosome | Xq23 |
| Protein Type | Channel |
| Function | TRPC5 is a member of the TRPC (Transient Receptor Potential Canonical) family with unique neuronal expression patterns and functions. |
| Primary Expression | brain, particularly in hippocampal and cortical neurons [2](https://pubmed |
| Ensembl ID | ENSG00000120336 |
| GeneCards | TRPC5 |
| Human Protein Atlas | TRPC5 |
| Neuronal Specificity | Highly expressed in brain, particularly in hippocampal and cortical neurons 2 |
| Gating | Activated by GPCR signaling, receptor tyrosine kinases, and mechanical stimuli 3 |
| Synaptic Function | Regulates dendritic spine morphology, synaptic transmission, and plasticity 4 |
| Development | Critical for neuronal development, axon guidance, and dendrite morphogenesis 5 |
| Intellectual Disability | Loss-of-function mutations cause X-linked intellectual disability 6 |
| Autism Spectrum Disorder | TRPC5 variants identified in patients with ASD 7 |
| Epilepsy | De novo mutations associated with epileptic encephalopathy 8 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TRPC5["TRPC5"]
neurodegeneration["neurodegeneration"]
TRPC5 -->|"implicated_in"| neurodegeneration
style TRPC5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity