gene

TTBK2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TTBK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	TTBK2
Full Name	Tau Tubulin Kinase 2
Chromosome	15q15.2
Protein Type	Kinase
Function	TTBK2 is a neuronal kinase with multiple functions:
Primary Expression	cerebellar Purkinje cells and involved in neuronal development, ciliary function, and tau phosphorylation
UniProt ID	Q8IWQ3
NCBI Gene ID	146057
Ensembl ID	ENSG00000146386
OMIM	611475
GeneCards	TTBK2
Human Protein Atlas	TTBK2
Tau phosphorylation	Phosphorylates tau at multiple AD-related sites
Ciliary function	Essential for ciliogenesis and hedgehog signaling
Neuronal development	Regulates Purkinje cell development and dendrite morphology
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TTBK2 — AlphaFold Q8IWQ3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TTBK2 Gene

gene · 553 words

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Pathway Diagram

graph TD
    TTBK2["TTBK2"]
    neurodegeneration["neurodegeneration"]
    TTBK2 -->|"implicated_in"| neurodegeneration
    style TTBK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TTBK2 in their description or question text

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