gene

TXNDC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TXNDC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TXNDC5 — Thioredoxin Domain Containing 5

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🧬 Gene Info

Gene Symbol	TXNDC5
Full Name	Thioredoxin Domain Containing 5
Chromosome	6p24.3
Function	TXNDC5 exhibits the following key functions
Primary Expression	Brain, Heart, Lung, Liver, Kidney, Platelets
UniProt ID	Q8N7T0
NCBI Gene ID	81567
Ensembl ID	ENSG00000213186
OMIM	614008
GeneCards	TXNDC5
Human Protein Atlas	TXNDC5
Protein Disulfide Isomerase Activity	Catalyzes disulfide bond formation and rearrangement in nascent proteins[@kojer2015]
ER Redox Homeostasis	Maintains the ER in a reduced state necessary for proper protein folding
Anti-apoptotic Function	Protects against ER stress-induced apoptosis through inhibition of CHOP expression[@tanaka2014]
Angiogenesis Regulation	Modulates endothelial cell function and blood vessel formation[@zhang2018]
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TXNDC5 — AlphaFold Q8N7T0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TXNDC5 — Thioredoxin Domain Containing 5

gene · 588 words

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Pathway Diagram

graph TD
    TXNDC5["TXNDC5"]
    neurodegeneration["neurodegeneration"]
    TXNDC5 -->|"implicated_in"| neurodegeneration
    style TXNDC5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TXNDC5 in their description or question text

No additional research found