Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about T_CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| SS | contributes_to | disease | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Senescent Cell ASM-Complement Cascade Intervention | 0.552 | neurodegeneration | Lipid raft composition changes in synapt |
| Senescent Cell Mitochondrial DNA Release | 0.545 | neurodegeneration | Senolytic therapy for age-related neurod |
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514
neurodegeneration | 2026-04-11 | 0 hypotheses
cell biology | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
synaptic biology | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757] | ["Bi D", "Yang X", "Wang Y", "Yong J", " | Frontiers in immunology | 2026 | 0 |
| Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577] | ["Zhou R", "Lin X", "Liao Z", "Lin J", " | Ageing research reviews | 2026 | 0 |
| Role of NEIL1 in genome maintenance. [PMID:40010204] | ["McCullough A", "Minko I", "Luzadder M" | DNA repair | 2025 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808] | ["Lai P", "Liu L", "Bancaro N", "Troiani | Immunity | 2025 | 0 |
| Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559] | ["Akgun Y"] | Ageing research reviews | 2025 | 0 |
| Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226] | ["Daubermann C", "Herhaus B", "Neuberger | Molecular biology reports | 2025 | 0 |
| Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587] | ["Song Z", "Xie X", "Chen Y", "Zhang B", | Immunity | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment s [PMID:39825014] | Chestnykh D, Mühle C, Schumacher F, Kali | Mol Psychiatry | 2025 | 0 |
| Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and P [PMID:40166037] | Cruchaga C, Heo G, Thomas A, Wang E, Oh | Res Sq | 2025 | 0 |
| Reduction of sphingomyelinase activity associated with progranulin deficiency an [PMID:40633679] | Boyle NR, Fox SN, Tadepalli AS, Seyfried | Neurobiol Dis | 2025 | 0 |
| Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604] | ["Orlikova-Boyer B", "Lorant A", "Gajula | Biomarker research | 2024 | 0 |
| Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Eff [PMID:39548919] | ["Li X", "Liu Y", "Ke J", "Wang Z", "Han | Advanced materials (Deerfield | 2024 | 0 |
| The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellul [PMID:39490400] | Zhang Y, Zou M, Wu H, Zhu J, Jin T | Neurobiology of disease | 2024 | 0 |
| mtDNA release promotes cGAS-STING activation and accelerated aging of postmitoti [PMID:39039044] | ["Li Y", "Cui J", "Liu L", "Hambright W" | Cell death & disease | 2024 | 0 |
| Senescent glia link mitochondrial dysfunction and lipid accumulation. [PMID:38839958] | ["Byrns C", "Perlegos A", "Miller K", "J | Nature | 2024 | 0 |
| Acid sphingomyelinase as a pathological and therapeutic target in neurological d [PMID:38337058] | Choi BJ, Park MH, Jin HK, Bae JS | Exp Mol Med | 2024 | 0 |
| EDIL3/Del-1 prevents aortic dissection through enhancing internalization and deg [PMID:38873925] | Yin Z, Zhang J, Zhao M, Liu J, Xu Y et a | Autophagy | 2024 | 0 |