entity

Trained Immunity

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Trained Immunity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

6Hypotheses

2Analyses

1Outgoing

7Incoming

0Experiments

4Debates

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Wiki Pages (1)

Knowledge base pages for this entity

Trained Immunity, Innate Memory, and Inflammaging

gap · 502 words

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Outgoing (1)

Target	Relation	Type	Str
neurodegeneration	causes	disease	0.50

Incoming (7)

Source	Relation	Type	Str
C1Q	modulates	protein	0.95
BCG	associated_with	drug	0.80
C1Q	associated_with	gene	0.70
inflammatory epigenetic scars	causes	process	0.70
SIRT1 activation	resets	process	0.70
histone demethylase inhibitors	inhibits	drug	0.50
KDM1A inhibitors	inhibits	drug	0.50

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train	0.712	neuroinflammation	What specific astrocyte-derived factors
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis	0.644	developmental-neurobiology	Do perinatal immune challenges create pe
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.380	developmental-neurobiology	Do perinatal immune challenges create pe
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.351	developmental-neurobiology	Do perinatal immune challenges create pe

Trained Immunity Metabolic Reset	0.000	-	Metabolic reprogramming in neurodegenera