gene

UBE2V1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBE2V1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The UBE2V1 gene encodes UEV-1, a ubiquitin-conjugating enzyme variant critical for K63-linked polyubiquitination, NF-κB signaling, DNA damage repair, and neurodegeneration.

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🧬 Gene Info

Gene Symbol	UBE2V1
Full Name	Ubiquitin-Conjugating Enzyme E2 Variant 1
Chromosome	20q13.33
Protein Family	Ubiquitin-conjugating enzyme (E2) family, UEV subfamily
Protein Type	Enzyme
Function	is a unique member of the ubiquitin-conjugating enzyme (E2) family.
Molecular Weight	17 kDa
Amino Acids	147 aa
Pathways	NF-κB
UniProt ID	[Q13435](https://www.uniprot.org/uniprot/Q13435)
Ensembl ID	ENSG00000109343
OMIM	603416
GeneCards	UBE2V1
Human Protein Atlas	UBE2V1
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

UBE2V1 Gene (UEV-1)

gene · 3333 words

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Pathway Diagram

graph TD
    UBE2V1["UBE2V1"]
    neurodegeneration["neurodegeneration"]
    UBE2V1 -->|"implicated_in"| neurodegeneration
    style UBE2V1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBE2V1 in their description or question text

No additional research found