gene

UBQLN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBQLN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

UBQLN3 (Ubiquilin 3) is a member of the ubiquilin family involved in protein quality control, with roles in proteasome-mediated degradation, autophagy, and protein aggregation. Implicated in ALS and FTD through genetic studies and protein interaction networks.

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🧬 Gene Info

Gene Symbol	UBQLN3
Full Name	Ubiquilin 3
Chromosome	Xp11.23
Function	is a member of the ubiquilin family of proteins that play critical roles in protein quality control.
Molecular Weight	71 kDa
Amino Acids	642 aa
Ensembl ID	ENSG00000166394
GeneCards	UBQLN3
Human Protein Atlas	UBQLN3
Aggregate clearance	UBQLN3 may help deliver protein aggregates to autophagosomes
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

UBQLN3 — Ubiquilin 3

gene · 1389 words

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Pathway Diagram

graph TD
    UBQLN3["UBQLN3"]
    neurodegeneration["neurodegeneration"]
    UBQLN3 -->|"implicated in"| neurodegeneration
    Als{"Als"}
    UBQLN3 -->|"implicated in"| Als
    Autophagy(["Autophagy"])
    UBQLN3 -->|"regulates"| Autophagy
    Protein_Aggregation(["Protein Aggregation"])
    UBQLN3 -->|"regulates"| Protein_Aggregation
    style UBQLN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Als fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Autophagy fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Protein_Aggregation fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning UBQLN3 in their description or question text

No additional research found