Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UCHL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | UCHL3 |
| Full Name | Ubiquitin carboxyl-terminal hydrolase L3 |
| Chromosome | 4p15.32 |
| Protein Type | Enzyme |
| Function | is a deubiquitinating enzyme (DUB) located on chromosome 4p15. |
| Primary Expression | the brain and plays critical roles in protein quality control, synaptic function, and neuronal survival |
| Amino Acids | 371 aa |
| Pathways | Wnt signaling |
| UniProt ID | P35536 |
| NCBI Gene ID | 7347 |
| Ensembl ID | ENSG00000135219 |
| OMIM | 604432 |
| GeneCards | UCHL3 |
| Human Protein Atlas | UCHL3 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
UCHL3["UCHL3"]
neurodegeneration["neurodegeneration"]
UCHL3 -->|"implicated_in"| neurodegeneration
style UCHL3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||