gene

UCHL3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about UCHL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for UCHL3 Gene

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🧬 Gene Info

Gene Symbol	UCHL3
Full Name	Ubiquitin carboxyl-terminal hydrolase L3
Chromosome	4p15.32
Protein Type	Enzyme
Function	is a deubiquitinating enzyme (DUB) located on chromosome 4p15.
Primary Expression	the brain and plays critical roles in protein quality control, synaptic function, and neuronal survival
Amino Acids	371 aa
Pathways	Wnt signaling
UniProt ID	P35536
NCBI Gene ID	7347
Ensembl ID	ENSG00000135219
OMIM	604432
GeneCards	UCHL3
Human Protein Atlas	UCHL3
Cysteine (Cys95)	Nucleophilic residue that attacks the ubiquitin-protein bond
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: UCHL3 — AlphaFold P35536 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

UCHL3 Gene

gene · 544 words

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Pathway Diagram

graph TD
    UCHL3["UCHL3"]
    neurodegeneration["neurodegeneration"]
    UCHL3 -->|"implicated_in"| neurodegeneration
    style UCHL3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning UCHL3 in their description or question text

No additional research found