Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UCP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Uncoupling Protein 4 - mitochondrial carrier involved in neuronal energy homeostasis and neuroprotection
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| Gene Symbol | UCP4 |
| Aliases | Uncoupling Protein 4 |
| Chromosome | 6p25.3 |
| Protein Type | Gene |
| Function | is a mitochondrial carrier protein primarily expressed in the nervous system. |
| Primary Expression | the nervous system |
| Molecular Weight | 34 kDa |
| Amino Acids | 307 aa |
| Exons | 9 |
| NCBI Gene ID | 285102 |
| GeneCards | UCP4 |
| Human Protein Atlas | UCP4 |
| Transport mechanism | Alternating access - substrate binding triggers conformational changes |
| Substrate specificity | Predominantly transports protons, may also transport other small molecules |
| N-terminal targeting sequence | Mitochondrial targeting peptide (first ~20 amino acids) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
UCP4["UCP4"]
neurodegeneration["neurodegeneration"]
UCP4 -->|"implicated_in"| neurodegeneration
style UCP4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning UCP4 in their description or question text
No additional research found