gene

ULF1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ULF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ULF1 Gene

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🧬 Gene Info

Gene Symbol	UFL1
Full Name	UFM1-Specific Ligase 1
Aliases	ULF1
Chromosome	6q24.2
Function	UFL1 is the E3 ligase for ufmylation
Primary Expression	neurons and glial cells: - Important for neuronal protein quality control - Highly expressed in [hippocampus](/brain-regions/hipp
UniProt ID	Q9GZL0
NCBI Gene ID	55297
Ensembl ID	ENSG00000134133
GeneCards	UFL1
Human Protein Atlas	UFL1
Protein ufmylation	Covalent attachment of UFM1 to target proteins
ER stress response	Critical for endoplasmic reticulum homeostasis
DNA repair	Involved in genome stability
Ribosome biogenesis	Regulates ribosomal protein function
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ULF1 — AlphaFold Q9GZL0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ULF1 Gene

gene · 759 words

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Pathway Diagram

graph TD
    ULF1["ULF1"]
    neurodegeneration["neurodegeneration"]
    ULF1 -->|"implicated_in"| neurodegeneration
    style ULF1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ULF1 in their description or question text

No additional research found