gene

USF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections
0Hypotheses
0Analyses
8Outgoing
1Incoming

Summary

USF2 is a gene implicated in neurodegeneration research. Key relationships include: implicated in, activates. Associated with Breast Cancer, Cancer, Tumor. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolUSF2
Full NameUpstream Transcription Factor 2
Chromosome19q13
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionCerebral cortex, Hippocampus, Liver, Muscle, Widespread
Molecular Weight~38 kDa
Amino Acids346 aa
UniProt IDQ13428
NCBI Gene ID7402
Ensembl IDENSG00000170608
OMIM601235
GeneCardsUSF2
Human Protein AtlasUSF2
Protein Length346 amino acids
Protein ClassbHLHZ Transcription Factor
Associated DiseasesTumor
InteractionsFUBP1, MYC, CANCER
KG Connections9 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: USF2 — AlphaFold Q13428 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

USF2 — Upstream Transcription Factor 2

gene · 671 words

USF2 Protein

protein · 1026 words

USF1 — Upstream Transcription Factor 1

gene · 828 words

USF1 Protein

protein · 755 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["USF2"]
    N1["Tumor"]
    N0 -->|"implicated in"| N1
    N2["Breast Cancer"]
    N0 -->|"activates"| N2
    N3["Cancer"]
    N0 -->|"activates"| N3
    N4["FUBP1"]
    N0 -->|"activates"| N4
    N5["CANCER"]
    N0 -->|"activates"| N5
    N6["MYC"]
    N0 -->|"activates"| N6
    N7["Metastasis"]
    N0 -->|"implicated in"| N7
    N8["Invasion"]
    N0 -->|"implicated in"| N8
    N9["GAIN"]
    N9 -->|"implicated in"| N0
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 pathway
    class N8 pathway
    class N9 gene

Outgoing (8)

TargetRelationTypeStr
Tumorimplicated_indisease0.65
Breast Canceractivatesdisease0.65
Canceractivatesdisease0.65
FUBP1activatesgene0.60
MYCactivatesgene0.60

Incoming (1)

SourceRelationTypeStr
GAINimplicated_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found