Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about USF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
USF2 is a gene implicated in neurodegeneration research. Key relationships include: implicated in, activates. Associated with Breast Cancer, Cancer, Tumor. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | USF2 |
| Full Name | Upstream Transcription Factor 2 |
| Chromosome | 19q13 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Cerebral cortex, Hippocampus, Liver, Muscle, Widespread |
| Molecular Weight | ~38 kDa |
| Amino Acids | 346 aa |
| UniProt ID | Q13428 |
| NCBI Gene ID | 7402 |
| Ensembl ID | ENSG00000170608 |
| OMIM | 601235 |
| GeneCards | USF2 |
| Human Protein Atlas | USF2 |
| Protein Length | 346 amino acids |
| Protein Class | bHLHZ Transcription Factor |
| Associated Diseases | Tumor |
| Interactions | FUBP1, MYC, CANCER |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["USF2"]
N1["Tumor"]
N0 -->|"implicated in"| N1
N2["Breast Cancer"]
N0 -->|"activates"| N2
N3["Cancer"]
N0 -->|"activates"| N3
N4["FUBP1"]
N0 -->|"activates"| N4
N5["CANCER"]
N0 -->|"activates"| N5
N6["MYC"]
N0 -->|"activates"| N6
N7["Metastasis"]
N0 -->|"implicated in"| N7
N8["Invasion"]
N0 -->|"implicated in"| N8
N9["GAIN"]
N9 -->|"implicated in"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 gene
class N5 gene
class N6 gene
class N7 pathway
class N8 pathway
class N9 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | implicated_in | disease | 0.65 |
| Breast Cancer | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| FUBP1 | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Metastasis | implicated_in | pathway | 0.60 |
| Invasion | implicated_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GAIN | implicated_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||