Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Tumor: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Tumors are abnormal masses of tissue that form when cells divide uncontrollably. In neurodegeneration research, brain tumors (gliomas, meningiomas) and their molecular pathways inform understanding of cell survival, proliferation, and death mechanisms. Shared pathways between tumorigenesis and neurodegeneration include p53 signaling, Wnt/beta-catenin, PI3K/AKT/mTOR, and autophagy.
| Associated Genes | IDH1, IDH2, HSPA1B, AGER, HSPA1A, PRMT1, VAMP8, LAMP2 |
| KG Connections | 4721 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
Tumor["Tumor"] -->|"regulates"| Epigenetic["Epigenetic"]
Tumor["Tumor"] -->|"activates"| Apoptosis["Apoptosis"]
Tumor["Tumor"] -.->|"inhibits"| Immune_Response["Immune Response"]
Tumor["Tumor"] -.->|"inhibits"| Glycolysis["Glycolysis"]
Tumor["Tumor"] -->|"activates"| Glycolysis_2["Glycolysis"]
Tumor["Tumor"] -->|"activates"| Mtor["Mtor"]
TNF["TNF"] -->|"activates"| Tumor["Tumor"]
CGAS["CGAS"] -->|"activates"| Tumor["Tumor"]
KRAS["KRAS"] -.->|"inhibits"| Tumor["Tumor"]
MYC["MYC"] -->|"activates"| Tumor["Tumor"]
SRC["SRC"] -->|"activates"| Tumor["Tumor"]
end
subgraph Therapeutic["Therapeutic"]
Tumor["Tumor"] -->|"therapeutic target"| Epigenetic_1["Epigenetic"]
Tumor["Tumor"] -->|"therapeutic target"| Autophagy["Autophagy"]
end
subgraph Pathology["Pathology"]
Tumor["Tumor"] -->|"associated with"| Aging["Aging"]
LC3["LC3"] -->|"associated with"| Tumor["Tumor"]
end
style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Immune_Response fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Epigenetic_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Glycolysis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Glycolysis_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style CGAS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style KRAS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MYC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style SRC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Epigenetic | regulates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Immune Response | inhibits | pathway | 1.00 |
| Epigenetic | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Glycolysis | inhibits | pathway | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Oxidative Phosphorylation | activates | pathway | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Lipid Metabolism | activates | pathway | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Angiogenesis | activates | pathway | 1.00 |
| Mtor | associated_with | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Wnt | activates | pathway | 1.00 |
| Er Stress | activates | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Ferroptosis | regulates | pathway | 1.00 |
| Lipid Metabolism | inhibits | pathway | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Toll-Like Receptor | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Tgf-Β | activates | pathway | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Mapk | therapeutic_target | pathway | 1.00 |
| Angiogenesis | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Glycolysis | therapeutic_target | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Oxidative Phosphorylation | therapeutic_target | pathway | 1.00 |
| Mapk | inhibits | pathway | 1.00 |
| Nf-Κb | therapeutic_target | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TNF | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| KRAS | inhibits | gene | 1.00 |
| LC3 | associated_with | gene | 1.00 |
| MYC | activates | gene | 1.00 |
| SRC | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| GBM | activates | gene | 1.00 |
| JUN | activates | gene | 1.00 |
| JUN | therapeutic_target | gene | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| TP53 | associated_with | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| TNF | expressed_in | gene | 1.00 |
| CD8 | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| MYC | associated_with | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| SLC7A11 | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| PTEN | therapeutic_target | gene | 1.00 |
| EGFR | activates | gene | 1.00 |
| BCL2 | activates | gene | 1.00 |
| MTOR | inhibits | gene | 1.00 |
| TNF | regulates | gene | 1.00 |
| TP53 | therapeutic_target | gene | 1.00 |
| TNF | associated_with | gene | 1.00 |
| TP53 | activates | gene | 1.00 |
| GAIN | activates | gene | 1.00 |
| STAT3 | inhibits | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| BRAF | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| BAX | inhibits | gene | 1.00 |
| BCL2 | inhibits | gene | 1.00 |
| GBM | associated_with | gene | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| DNA | interacts_with | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| DNA | regulates | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
neuro-oncology | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-13 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||