gene

GAIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1870Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

2Experiments

0Debates

Summary

Page for GAIN Gene - GABA-A Receptor Associated Protein Like 2

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🧬 Gene Info

Gene Symbol	GAIN
Full Name	GAIN - GABA-A Receptor Associated Protein Like 2
Aliases	Page for GAIN Gene, GABARAPL2
Chromosome	16p13.3
Protein Type	Gene
Function	encodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family.
Primary Expression	various tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism
NCBI Gene ID	124454
GeneCards	GAIN
Human Protein Atlas	GAIN
Associated Diseases	aging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Interactions	ACAT1, ACC, ACHE, Actin, AGING, AIF
KG Connections	1870 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GAIN Gene - GABA-A Receptor Associated Protein Like 2

gene · 585 words

→

GAIN Protein (GABARAPL2) - GABA-A Receptor Associated Protein Like 2

protein · 673 words

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Pathway Diagram

graph TD
    GAIN["GAIN"] -->|"activates"| Cancer["Cancer"]
    GAIN["GAIN"] -->|"activates"| Carcinoma["Carcinoma"]
    GAIN["GAIN"] -->|"activates"| Ms["Ms"]
    GAIN["GAIN"] -->|"activates"| Als["Als"]
    GAIN["GAIN"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    GAIN["GAIN"] -->|"biomarker for"| Inflammation["Inflammation"]
    TIGAR["TIGAR"] -->|"activates"| GAIN["GAIN"]
    IDH2["IDH2"] -->|"activates"| GAIN["GAIN"]
    TMEM119["TMEM119"] -->|"biomarker for"| GAIN["GAIN"]
    P2RY12["P2RY12"] -->|"biomarker for"| GAIN["GAIN"]
    style GAIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1279)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Als	causes	disease	1.00
Neurodegeneration	activates	disease	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
CANCER	associated_with	gene	1.00
Cancer	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Tumor	inhibits	disease	1.00
Cancer	associated_with	disease	1.00
Tumor	associated_with	disease	1.00
Als	associated_with	disease	1.00
GENES	activates	gene	1.00
Apoptosis	activates	pathway	1.00
Apoptosis	implicated_in	pathway	1.00
INFLAMMATION	activates	gene	1.00
PI3K	therapeutic_target	gene	1.00
Als	expressed_in	disease	0.95
Inflammation	regulates	disease	0.95
Inflammation	therapeutic_target	disease	0.95
Aging	therapeutic_target	disease	0.95
Cancer	causes	disease	0.95
Tumor	therapeutic_target	disease	0.95
DNA	therapeutic_target	gene	0.90
Autophagy	activates	pathway	0.90
CANCER	activates	gene	0.90
GENES	therapeutic_target	gene	0.90
DNA	activates	gene	0.90
AKT	therapeutic_target	gene	0.90
Autoimmune	therapeutic_target	disease	0.85
Cancer	inhibits	disease	0.85
Breast Cancer	therapeutic_target	disease	0.85
Obesity	activates	disease	0.85
Diabetes	therapeutic_target	disease	0.85
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.85
ASTROCYTES	activates	gene	0.80
P53	associated_with	gene	0.80
Immune Response	activates	pathway	0.80
DNA	associated_with	gene	0.80
GENES	associated_with	gene	0.80
Autophagy	implicated_in	pathway	0.80
Glycolysis	activates	pathway	0.80
TP53	implicated_in	gene	0.80
Nf-Κb	activates	pathway	0.80
ALS	causes	gene	0.80
Oxidative Stress	activates	pathway	0.80
AMYLOID	activates	gene	0.80
Cell Cycle	implicated_in	pathway	0.80

Incoming (591)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	implicated_in	gene	1.00
PTEN	therapeutic_target	gene	0.90
GENES	therapeutic_target	gene	0.90
NEURODEGENERATION	activates	gene	0.80
HUNTINGTON	associated_with	gene	0.70
TNF	regulates	gene	0.70
PIEZO1	associated_with	gene	0.70
PINK1	therapeutic_target	gene	0.70
AUTOPHAGY	activates	gene	0.70
TREM2	activates	gene	0.70
DNA	associated_with	gene	0.70
C9ORF72	activates	gene	0.70
SOD1	therapeutic_target	gene	0.70
DNA	therapeutic_target	gene	0.70
CANCER	biomarker_for	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
C9ORF72	protects_against	gene	0.60
FIG4	expressed_in	gene	0.60
JUN	activates	gene	0.60
ALS2	expressed_in	gene	0.60
SUCLG1	regulates	gene	0.60
STING1	associated_with	gene	0.60
HSP70	activates	gene	0.60
CALB1	associated_with	gene	0.60
KCNN3	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
TKT	activates	gene	0.60
OPTN	expressed_in	gene	0.60
VCP	activates	gene	0.60
TMEM119	biomarker_for	gene	0.60
STING	associated_with	gene	0.60
CD8	expressed_in	gene	0.60
TIA1	activates	gene	0.60
TP53	activates	gene	0.60
SOD1	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
CHUK	inhibits	gene	0.60
PIK3CA	associated_with	gene	0.60
SOX2	biomarker_for	gene	0.60
ATM	biomarker_for	gene	0.60
P62	inhibits	gene	0.60
RANKL	activates	gene	0.60
BRAF	therapeutic_target	gene	0.60
TET2	therapeutic_target	gene	0.60
STAT3	activates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
GABRA1	associated_with	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
G2019S primarily raises baseline LRRK2 kinase activity rathe	0.790	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resil	0.778	neurodegeneration	Gut Microbiome Analysis in Parkinson's D
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.698	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against T	0.604	neurodegeneration	Should microtubule-stabilizing drugs be
ω-3 Docosahexaenoic Acid (DHA) Metabolism via 15-Lipoxygenas	0.380	lipidomics	Lipid metabolism dysregulation in Alzhei

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PGC-1α knockout analysis of PV+ interneuron maturation	validation	neurodevelopmental disorders	0.850	0.00	knockout mice	proposed	N/A
PV+ interneuron subtype diversification analysis	exploratory	neurodevelopmental disorders	0.750	0.00	mouse cortical PV+ interneuron	proposed	N/A

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopa [PMID:41128923]	Buck SA, Malankhanova T, Strader S, Ma E	Acta neuropathologica	2025
RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome hom [PMID:39343966]	Li X, Zhu H, Huang BT, Li X, Kim H, Tan	Nature communications	2024
Exploring the focal role of LRRK2 kinase in Parkinson's disease. [PMID:35147886]	["Kumar Sachin", "Behl Tapan", "Sehgal A	Environmental science and poll	2022
Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease. [PMID:35521944]	Wang S, Unnithan S, Bryant N	Mov Disord	2022
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Rab GTPases as Physiological Substrates of LRRK2 Kinase. [PMID:31138985]	Seol W, Nam D, Son I	Exp Neurobiol	2019
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GAIN in their description or question text

No additional research found