Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Cancer is a group of diseases involving abnormal cell growth with potential to invade or spread to other parts of the body. In the context of neuroscience research, the relationship between cancer and neurodegeneration is complex — epidemiological studies show inverse associations between several cancers and Alzheimer's or Parkinson's disease, suggesting shared but opposing molecular mechanisms.
| Associated Genes | IDH1, IDH2, TP53, EFNB1, EPHB4, PRMT1, PIEZO1, KCNK2 |
| Therapeutic Agents | NAMPT Inhibitors, Chronochemotherapy, Fisetin, Quercetin, Chemotherapy, Cannabigerol |
| KG Connections | 6327 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
subgraph Therapeutic["Therapeutic"]
Cancer["Cancer"] -->|"therapeutic target"| Wnt["Wnt"]
JUN["JUN"] -->|"therapeutic target"| Cancer["Cancer"]
VEGFA["VEGFA"] -->|"therapeutic target"| Cancer["Cancer"]
MET["MET"] -->|"therapeutic target"| Cancer["Cancer"]
OVERVIEW_1["OVERVIEW"] -->|"therapeutic target"| Cancer["Cancer"]
end
subgraph Pathology["Pathology"]
Cancer["Cancer"] -->|"associated with"| Als["Als"]
Cancer["Cancer"] -->|"associated with"| Neurodegeneration["Neurodegeneration"]
Cancer["Cancer"] -->|"associated with"| Tumor["Tumor"]
Cancer["Cancer"] -->|"associated with"| Autoimmune["Autoimmune"]
Cancer["Cancer"] -->|"associated with"| Apoptosis["Apoptosis"]
Cancer["Cancer"] -->|"associated with"| Aging["Aging"]
OVERVIEW["OVERVIEW"] -->|"biomarker for"| Cancer["Cancer"]
end
subgraph Signaling["Signaling"]
Cancer["Cancer"] -->|"activates"| Glycolysis["Glycolysis"]
Cancer["Cancer"] -->|"regulates"| Epigenetic["Epigenetic"]
GAIN["GAIN"] -->|"activates"| Cancer["Cancer"]
end
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Wnt fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Glycolysis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autoimmune fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style JUN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style VEGFA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MET fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style GAIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OVERVIEW fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OVERVIEW_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Wnt | therapeutic_target | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Epigenetic | regulates | pathway | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Autoimmune | associated_with | disease | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Immune Response | inhibits | pathway | 1.00 |
| Epigenetic | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Glycolysis | inhibits | pathway | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Mtor | interacts_with | pathway | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| Wnt | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Oxidative Phosphorylation | activates | pathway | 1.00 |
| Lipid Metabolism | activates | pathway | 1.00 |
| Lipid Metabolism | associated_with | pathway | 1.00 |
| Wnt | associated_with | pathway | 1.00 |
| Atherosclerosis | associated_with | disease | 1.00 |
| Lymphoma | associated_with | disease | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Lipid Metabolism | regulates | pathway | 1.00 |
| Ferroptosis | regulates | pathway | 1.00 |
| Angiogenesis | activates | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Mtor | associated_with | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Immune Response | associated_with | pathway | 1.00 |
| Glycolysis | associated_with | pathway | 1.00 |
| Innate Immunity | activates | pathway | 1.00 |
| Obesity | associated_with | disease | 1.00 |
| Phagocytosis | activates | pathway | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Er Stress | activates | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| JUN | therapeutic_target | gene | 1.00 |
| VEGFA | therapeutic_target | gene | 1.00 |
| MET | therapeutic_target | gene | 1.00 |
| GAIN | activates | gene | 1.00 |
| OVERVIEW | biomarker_for | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| TP53 | associated_with | gene | 1.00 |
| FASN | activates | gene | 1.00 |
| KRAS | inhibits | gene | 1.00 |
| MYC | activates | gene | 1.00 |
| TP53 | therapeutic_target | gene | 1.00 |
| HK2 | activates | gene | 1.00 |
| SRC | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| CLOCK | associated_with | gene | 1.00 |
| SRC | therapeutic_target | gene | 1.00 |
| BAX | inhibits | gene | 1.00 |
| BCL2 | inhibits | gene | 1.00 |
| SQSTM1 | regulates | gene | 1.00 |
| MYC | associated_with | gene | 1.00 |
| LC3 | associated_with | gene | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| CD8 | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| APP | associated_with | gene | 1.00 |
| MYC | regulates | gene | 1.00 |
| GPX4 | regulates | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| SLC7A11 | activates | gene | 1.00 |
| ATM | activates | gene | 1.00 |
| OVERVIEW | regulates | gene | 1.00 |
| BECN1 | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| MYC | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| EGFR | activates | gene | 1.00 |
| CD8 | therapeutic_target | gene | 1.00 |
| CD8 | inhibits | gene | 1.00 |
| KRAS | activates | gene | 1.00 |
| TP53 | activates | gene | 1.00 |
| STAT3 | therapeutic_target | gene | 1.00 |
| STAT3 | inhibits | gene | 1.00 |
| MTOR | inhibits | gene | 1.00 |
| GPX4 | inhibits | gene | 1.00 |
| EGF | activates | gene | 1.00 |
| NRF2 | regulates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||