Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Breast Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | MCOLN1, KLHL22, DEPDC5, CANCER, NEURODEGENERATION, GLIOBLASTOMA, MTOR, BRCA1 |
| Therapeutic Agents | 5A, Fisetin, Sy-1365, PI3K Inhibitors, AKT Inhibitors, mTOR Inhibitors |
| KG Connections | 802 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Breast_Cancer["<b>Breast Cancer</b>"]
Cancer{"Cancer"}
Breast_Cancer -->|"causes"| Cancer
Als{"Als"}
Breast_Cancer -->|"treats"| Als
Metastasis["Metastasis"]
Breast_Cancer -->|"therapeutic_target"| Metastasis
Pi3K_Akt["Pi3K/Akt"]
Breast_Cancer -->|"therapeutic_target"| Pi3K_Akt
CANCER(["CANCER"])
CANCER -->|"causes"| Breast_Cancer
Tumor{"Tumor"}
Tumor -->|"treats"| Breast_Cancer
style Breast_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | causes | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | treats | disease | 1.00 |
| Cancer | treats | disease | 1.00 |
| Metastasis | therapeutic_target | pathway | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Cancer | implicated_in | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Apoptosis | treats | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| Metastasis | activates | pathway | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Metastasis | treats | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Metastasis | associated_with | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Invasion | inhibits | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Immune Checkpoint | inhibits | pathway | 1.00 |
| Cancer | expressed_in | disease | 0.95 |
| Carcinoma | associated_with | disease | 0.95 |
| White Population | associated_with | phenotype | 0.95 |
| Angiogenesis | therapeutic_target | pathway | 0.90 |
| Pi3K/Akt | inhibits | pathway | 0.90 |
| Epithelial-Mesenchymal Transition | inhibits | pathway | 0.90 |
| Mtor | treats | pathway | 0.90 |
| Pi3K/Akt | treats | pathway | 0.90 |
| Stem Cell | inhibits | pathway | 0.90 |
| Metastasis | inhibits | pathway | 0.90 |
| Nf-Κb | therapeutic_target | pathway | 0.90 |
| Mitophagy | activates | pathway | 0.90 |
| Apoptosis | implicated_in | pathway | 0.90 |
| Als | biomarker_for | disease | 0.85 |
| Metastasis | causes | pathway | 0.80 |
| Metastasis | expressed_in | pathway | 0.80 |
| Epigenetic | inhibits | pathway | 0.80 |
| Mapk | therapeutic_target | pathway | 0.80 |
| Mtor | activates | pathway | 0.80 |
| Chemoresistance | therapeutic_target | pathway | 0.80 |
| Autophagy | inhibits | pathway | 0.80 |
| Autophagy | regulates | pathway | 0.80 |
| Ferroptosis | regulates | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | causes | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Tumor | treats | disease | 1.00 |
| CANCER | treats | gene | 1.00 |
| PTEN | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| CANCER | regulates | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| MTOR | inhibits | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| CANCER | expressed_in | gene | 1.00 |
| CANCER | implicated_in | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| PI3K | treats | gene | 1.00 |
| AKT | treats | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| APOPTOSIS | treats | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | regulates | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| STAT3 | therapeutic_target | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| MIRNAS | implicated_in | gene | 1.00 |
| HER2 | associated_with | protein | 0.98 |
| ERBB2 | associated_with | gene | 0.98 |
| 5A | treats | compound | 0.95 |
| miR-139-5p | associated_with | biomarker | 0.95 |
| Tumor | expressed_in | disease | 0.95 |
| AKT | inhibits | gene | 0.95 |
| CANCER | contributes_to | gene | 0.95 |
| Tumor | implicated_in | disease | 0.95 |
| MTOR | treats | gene | 0.95 |
| OVERVIEW | therapeutic_target | gene | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||