USP14

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolUSP14
Nameubiquitin specific peptidase 14
Typeprotein-coding
Sourcemygene

Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to

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