Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VAMP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | VAMP1 |
| Protein Type | Receptor |
| Function | VAMP1 is an integral membrane protein localized to synaptic vesicles. |
| Subcellular Localization | synaptic vesicles. It functions as a v-SNARE (vesicular SNARE) and pairs with t-SNAREs (target SNAREs) such as SNAP-25 a |
| Molecular Weight | 12.6 kDa |
| Amino Acids | 116 aa |
| Ensembl ID | ENSG00000139193 |
| GeneCards | VAMP1 |
| Human Protein Atlas | VAMP1 |
| Gene therapy | AAV-VAMP1 for SMA (experimental) |
| Small molecule SNARE modulators | Under investigation |
| Botulinum neurotoxin studies | Understanding mechanism |
| Vamp1 knockout mice | Viable but show neuromuscular deficits |
| Transgenic models | Overexpression studies |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VAMP1["VAMP1"]
neurodegeneration["neurodegeneration"]
VAMP1 -->|"implicated_in"| neurodegeneration
style VAMP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||