protein

VAMP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for VAMP1 Protein

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🔬 Protein Info

Gene Symbol	VAMP1
Protein Type	Receptor
Function	VAMP1 is an integral membrane protein localized to synaptic vesicles.
Subcellular Localization	synaptic vesicles. It functions as a v-SNARE (vesicular SNARE) and pairs with t-SNAREs (target SNAREs) such as SNAP-25 a
Molecular Weight	12.6 kDa
Amino Acids	116 aa
Ensembl ID	ENSG00000139193
GeneCards	VAMP1
Human Protein Atlas	VAMP1
Gene therapy	AAV-VAMP1 for SMA (experimental)
Small molecule SNARE modulators	Under investigation
Botulinum neurotoxin studies	Understanding mechanism
Vamp1 knockout mice	Viable but show neuromuscular deficits
Transgenic models	Overexpression studies
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VAMP1 Gene

gene · 653 words

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VAMP1 Protein

protein · 610 words

→

Pathway Diagram

graph TD
    VAMP1["VAMP1"]
    neurodegeneration["neurodegeneration"]
    VAMP1 -->|"implicated_in"| neurodegeneration
    style VAMP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning VAMP1 in their description or question text

No additional research found