gene

VPS37C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS37C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

VPS37C encodes a subunit of the ESCRT-I complex essential for endosomal trafficking and multivesicular body formation. Critical for protein clearance, autophagy, and lysosomal degradation. Dysfunction linked to Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	VPS37C
Full Name	Vacuolar Protein Sorting 37 Homolog C
Chromosome	15q21.3
Function	encodes a subunit of the ESCRT-I (Endosomal Sorting Complex Required for Transport I) complex, which plays essential roles in endosomal trafficking and multivesicular body (MVB) formation[@escrti20...
Amino Acids	312 aa
Exons	7
UniProt ID	Q9H0M4
NCBI Gene ID	256364
Ensembl ID	ENSG00000170876
OMIM	614618
GeneCards	VPS37C
Human Protein Atlas	VPS37C
2001	ESCRT complexes identified
2005	Mammalian ESCRT characterized
2010	VPS37C characterized
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VPS37C — AlphaFold Q9H0M4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VPS37C Gene

gene · 1184 words

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Pathway Diagram

graph TD
    VPS37C["VPS37C"]
    neurodegeneration["neurodegeneration"]
    VPS37C -->|"implicated in"| neurodegeneration
    Alzheimer_S{"Alzheimer'S"}
    VPS37C -->|"implicated in"| Alzheimer_S
    Parkinson_S_Disease{"Parkinson'S Disease"}
    VPS37C -->|"implicated in"| Parkinson_S_Disease
    Autophagy(["Autophagy"])
    VPS37C -->|"regulates"| Autophagy
    style VPS37C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Alzheimer_S fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Autophagy fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning VPS37C in their description or question text

No additional research found