gene

VPS51

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS51: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The VPS51 gene encodes a critical subunit of the GARP complex, essential for endosome-to-Golgi retrograde transport and membrane trafficking in neurons.

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🧬 Gene Info

Gene Symbol	VPS51
Full Name	Vacuolar Protein Sorting 51
Chromosome	11q13.2
Protein Family	GARP complex, HOPS complex
Function	encodes a critical subunit of the GARP (Golgi-Associated Retrograde Protein) complex, a multiprotein complex essential for endosome-to-Golgi retrograde transport.
Molecular Weight	112 kDa
UniProt ID	Q9NZJ5
NCBI Gene ID	55750
Ensembl ID	ENSG00000167523
OMIM	613362
GeneCards	VPS51
Human Protein Atlas	VPS51
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VPS51 — AlphaFold Q9NZJ5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VPS51 Gene

gene · 1759 words

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VPS51 Protein

protein · 812 words

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Pathway Diagram

graph TD
    VPS51["VPS51"]
    neurodegeneration["neurodegeneration"]
    VPS51 -->|"implicated_in"| neurodegeneration
    style VPS51 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VPS51 in their description or question text

No additional research found