gene

WASHC1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about WASHC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

WASHC1 — WASH Complex Subunit 1

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🧬 Gene Info

Gene Symbol	WASHC1
Full Name	WASH Complex Subunit 1
Chromosome	9
Function	WASH complex subunit 1 (WASHC1) is a critical component of the WASH (Wiskott-Aldrich syndrome protein and SCAR homologue) complex, which regulates actin polymerization and endosomal trafficking.
Ensembl ID	ENSG00000197746
GeneCards	WASHC1
Human Protein Atlas	WASHC1
Endosomal transport	The WASH complex regulates retrograde transport from early endosomes to the trans-Golgi network (TGN)
Autophagosome formation	WASHC1 is involved in autophagy through its role in endosomal trafficking and cargo sorting[@phillipskrawczak2021]
Dendritic spine morphogenesis	In neurons, WASHC1 localizes to dendritic compartments and regulates spine development through actin cytoskeleton remodeling
Brain	Cerebral cortex, hippocampus, basal ganglia, and cerebellum
High expression in neurons	Particularly in dendritic arborizations and growth cones
Cellular localization	Primarily endosomal membranes, with enrichment in early endosomes and recycling endosomes
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WASHC1 — WASH Complex Subunit 1

gene · 619 words

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Pathway Diagram

graph TD
    WASHC1["WASHC1"]
    neurodegeneration["neurodegeneration"]
    WASHC1 -->|"implicated_in"| neurodegeneration
    style WASHC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning WASHC1 in their description or question text

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