protein

WDR45B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WDR45B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

WDR45B Protein - WDR45B is a WD40 repeat protein involved in autoph...

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🔬 Protein Info

Gene Symbol	WDR45B
Full Name	WD Repeat Domain 45B
Aliases	WDR45B Protein
Function	is a WD repeat protein that plays a critical role in autophagy, specifically in the formation and function of autophagosomes.
Primary Expression	the brain [@toney2019]
Molecular Weight	44.6 kDa
Pathways	PI3K
Ensembl ID	ENSG00000160087
GeneCards	WDR45B
Human Protein Atlas	WDR45B
WD repeats	5-6 WD repeat motifs forming a beta-propeller
N-terminal region	Involved in protein interactions
Autophagosome formation	Required for initiation of autophagy
Selective autophagy	Involved in specific cargo recognition
Lipid metabolism	Affects membrane dynamics
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WDR45B — WD Repeat Domain 45B

gene · 775 words

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WDR45B Protein

protein · 588 words

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Pathway Diagram

graph TD
    WDR45B["WDR45B"]
    neurodegeneration["neurodegeneration"]
    WDR45B -->|"implicated_in"| neurodegeneration
    style WDR45B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning WDR45B in their description or question text

No additional research found