Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WNT16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | Wingless-Type MMTV Integration Site Family Member 16 |
| Chromosome | 7q31.31 |
| Function | is a secreted signaling protein that plays essential roles in bone metabolism, embryonic development, and cellular homeostasis. |
| Gene Type | Protein Coding |
| Pathways | WNT, Wnt, Wnt pathway, Wnt Signaling |
| UniProt ID | Q9Y5Q4 |
| NCBI Gene ID | 4253 |
| Ensembl ID | ENSG00000002746 |
| OMIM | 616933 |
| Signal peptide | For secretion |
| Wnt domain | Conserved functional region |
| Cysteine-rich region | Essential for receptor interactions |
| Lipid modification | Palmitoylation site |
| Bone | Osteoblasts, osteocytes |
| Brain | Neurons, glia |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
WNT16["WNT16"]
neurodegeneration["neurodegeneration"]
WNT16 -->|"implicated_in"| neurodegeneration
style WNT16 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning WNT16 in their description or question text
No additional research found