gene

ZNF512B

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ZNF512B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ZNF512B (Zinc Finger Protein 512B) - C2H2 zinc finger transcription factor implicated in ALS susceptibility, RNA processing, and neuronal stress response.

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🧬 Gene Info

Gene Symbol	ZNF512B
Aliases	Zinc Finger Protein 512B
Chromosome	12p12.1
Function	is a C2H2-type zinc finger protein encoding gene located on chromosome 12p12.
Primary Expression	neural tissues, including the motor cortex, spinal cord, and brainstem motor nuclei
Amino Acids	724 aa
Exons	4
GeneCards	ZNF512B
Human Protein Atlas	ZNF512B
N-terminal repression domain	Contains a transcriptional repression motif
C2H2 zinc finger cluster	Six zinc finger domains in tandem arrangement
C-terminal regulatory region	Involved in protein-protein interactions
Direct DNA binding	The zinc finger domains recognize specific sequences in target gene promoters
Transcriptional activation/repression	Depending on context and interacting partners
Chromatin interaction	May influence chromatin structure and accessibility
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ZNF512B Gene

gene · 1494 words

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Pathway Diagram

graph TD
    ZNF512B["ZNF512B"]
    neurodegeneration["neurodegeneration"]
    ZNF512B -->|"implicated_in"| neurodegeneration
    style ZNF512B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

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