gene

ZRANB3

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This page aggregates everything SciDEX knows about ZRANB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ZRANB3 — Zinc Finger RanBP2-Type Containing 3

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🧬 Gene Info

Gene Symbol	ZRANB3
Full Name	Zinc Finger RanBP2-Type Containing 3
Chromosome	2q14.3
Function	is a DNA-dependent ATPase and endonuclease critical for the resolution of DNA replication stress and the maintenance of genome stability.
Subcellular Localization	to sites of replication stress [3] - Genome Stability Maintenance: Prevents
Ensembl ID	ENSG00000162738
GeneCards	ZRANB3
Human Protein Atlas	ZRANB3
Replication Fork Remodeling	Reverses stalled replication forks by branch migration, converting damaged forks into structures amenable to repair
DNA Annealing Activity	Promotes strand annealing during DNA repair synthesis
Endonuclease Activity	Cleaves DNA structures during repair processing
PCNA Interaction	Recruits to stalled forks via PCNA interaction, ensuring proper localization to sites of replication stress [3]
Genome Stability Maintenance	Prevents chromosomal instability that can lead to cell death or transformation
[PCNA](/proteins/pcna-protein)	Sliding clamp that recruits ZRANB3 to stalled forks
[RAD51](/genes/rad51)	Recombinase involved in homologous recombination repair
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ZRANB3 — Zinc Finger RanBP2-Type Containing 3

gene · 1063 words

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Pathway Diagram

graph TD
    ZRANB3["ZRANB3"]
    neurodegeneration["neurodegeneration"]
    ZRANB3 -->|"implicated_in"| neurodegeneration
    style ZRANB3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning ZRANB3 in their description or question text

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