Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about aggregate clearance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| p62/SQSTM1 phosphorylation (Ser403) | activates | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-Mediated Selective Aggregate Clearance Pathway | 0.584 | neurodegeneration | Protein aggregation cross-seeding across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.772
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.200 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting TREM2 to disentangle neuroinflammation and α-Syn pathological propagat [PMID:41833769] | Chen Y, Wang H, Wang J, Wei J | Cellular signalling | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven Gamze; Gezegen Haşim; & | Acta neurologica Belgica | 2026 | 0 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896] | Chen G, Wang Z, Zhao C, Wang C, Li Y et | Am J Pathol | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
| Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell [PMID:41928407] | Shen HC, Chen NJ, Sun CY, Yu WK, Su VY e | Kaohsiung J Med Sci | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | Neuroscientist | 2025 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | The Neuroscientist : a review | 2025 | 0 |
| Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid [PMID:41261421] | Etani H, Takatori S, Wang W, Omi J, Amiy | Alzheimer's research & therapy | 2025 | 0 |
| TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the pr [PMID:36368315] | Gratuze M, Schlachetzki JCM, D'Oliveira | Neuron | 2023 | 0 |
| TREM2 receptor protects against complement-mediated synaptic loss by binding to [PMID:37442133] | Zhong L, Sheng X, Wang W, Li Y, Zhuo R, | Immunity | 2023 | 0 |
| Too naïve to lead: When leaders fall for flattery. [PMID:37796590] | Rogers BA, Sezer O, Klein N | Journal of personality and soc | 2023 | 0 |
| Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clear [PMID:35672148] | ["Shi Qian", "Chang Cheng", "Saliba Afaf | The Journal of neuroscience : | 2022 | 0 |
| TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP- [PMID:34916658] | Xie M, Liu YU, Zhao S, Zhang L, Bosco DB | Nature neuroscience | 2022 | 0 |
| Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions. [PMID:33028628] | Luhur A, Mariyappa D, Klueg KM, Buddika | G3 (Bethesda, Md.) | 2020 | 0 |
| Author Correction: Identification of TC2N as a novel promising suppressor of PI3 [PMID:31235687] | Hao XL, Gao LY, Deng XJ, Han F, Chen HQ, | Cell death & disease | 2019 | 0 |
| Predictive Role of High Blood Pressure for the Incidence of Metabolic Syndrome. [PMID:31261156] | Presta V, Miceli F, Tocci G | Cardiology | 2019 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning aggregate clearance in their description or question text
No additional research found