disease

als-progression-rate-heterogeneity

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about als-progression-rate-heterogeneity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

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Disease Info

Prevalence	3-8% of cases
Typical Onset	Lower limb onset
Progression	Median survival 5-15 years
Progression pattern	Steady decline, typically faster after respiratory onset
Challenge	Often considered separately due to faster progression
Note	Some consider PLS a distinct entity from ALS
Characteristic	"Man-in-the-barrel" phenotype
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    als_progression_rate_heterogeneity["als-progression-rate-heterogeneity"]
    ALS["ALS"]
    als_progression_rate_heterogeneity -->|"associated_with"| ALS
    HOXB13["HOXB13"]
    als_progression_rate_heterogeneity -->|"inhibits"| HOXB13
    als_progression_rate_heterogeneity -->|"activates"| ALS
    PRESENILIN["PRESENILIN"]
    als_progression_rate_heterogeneity -->|"activates"| PRESENILIN
    NPY["NPY"]
    als_progression_rate_heterogeneity -->|"interacts_with"| NPY
    ABCA7["ABCA7"]
    als_progression_rate_heterogeneity -->|"associated_with"| ABCA7
    als_progression_rate_heterogeneity -->|"implicated_in"| ALS
    TAU_PATHOLOGY["TAU PATHOLOGY"]
    als_progression_rate_heterogeneity -->|"contributes_to"| TAU_PATHOLOGY
    als_progression_rate_heterogeneity -->|"accumulates_in"| ALS
    als_progression_rate_heterogeneity -->|"protects_against"| ALS
    TRKB["TRKB"]
    als_progression_rate_heterogeneity -->|"associated_with"| TRKB
    LC3["LC3"]
    als_progression_rate_heterogeneity -->|"interacts_with"| LC3
    style als_progression_rate_heterogeneity fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style HOXB13 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style PRESENILIN fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NPY fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ABCA7 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style TAU_PATHOLOGY fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style TRKB fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style LC3 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

als-progression-rate-heterogeneity

Understanding Entity Pages

Wiki Pages (8)