Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about brain region: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| 33796061 | showed differences in | paper | 0.90 |
| Microglia | expressed_in | cell_type | 0.90 |
| astrocyte heterogeneity | associated_with | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| VPS35 retromer activation prevents endosomal tau templating | 0.740 | neurodegeneration | Which tau propagation mechanism predomin |
| Age-driven synaptic gene silencing precedes neuronal loss in | 0.390 | Alzheimer's disease | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.844
neurodegeneration | 2026-04-10 | 0 hypotheses
neuroscience | 2026-04-04 | 9 hypotheses Top: 0.822
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.640
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405] | Li S, Yan Z, Zhi X, Zheng W, Zhang Z et | Bioact Mater | 2026 | 0 |
| Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939] | Wan D, Qi Y, Kang Y, Liang F, Wang Q et | RSC Med Chem | 2026 | 0 |
| Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906] | Gao Z, Wang Y, Ren Y, Lyu J | J Neurochem | 2026 | 0 |
| VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560] | Lee S, Park S, Bang H, Kim SU, Park YH e | Genes (Basel) | 2026 | 0 |
| N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663] | Song P, Chen C, Franchini R, Duong B, Wa | J Clin Invest | 2026 | 0 |
| The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708] | Buneeva OA, Medvedev AE | Biomed Khim | 2026 | 0 |
| Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978] | Deng IB, Bu M, Follett J, Sharp R, Mamai | bioRxiv | 2026 | 0 |
| Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440] | Santinelli L, Pratuseviciute N, Lange LM | Mov Disord | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.34 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
Hypotheses and analyses mentioning brain region in their description or question text
No additional research found