c9orf72-repeat-expansion-als

Understanding Entity Pages

This page aggregates everything SciDEX knows about c9orf72-repeat-expansion-als: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    C9ORF72["C9ORF72"]
    DEMENTIA["DEMENTIA"]
    C9ORF72 -->|"activates"| DEMENTIA
    TDP_43["TDP-43"]
    C9ORF72 -->|"inhibits"| TDP_43
    C9ORF72 -->|"associated_with"| TDP_43
    Dementia["Dementia"]
    C9ORF72 -->|"expressed_in"| Dementia
    STAU1["STAU1"]
    C9ORF72 -->|"therapeutic_target"| STAU1
    C9ORF72 -->|"activates"| Dementia
    ATP13A2["ATP13A2"]
    C9ORF72 -->|"associated_with"| ATP13A2
    SMCR8["SMCR8"]
    C9ORF72 -->|"inhibits"| SMCR8
    Schizophrenia["Schizophrenia"]
    C9ORF72 -->|"expressed_in"| Schizophrenia
    ALS["ALS"]
    C9ORF72 -->|"regulates"| ALS
    RICTOR["RICTOR"]
    C9ORF72 -->|"activates"| RICTOR
    CHMP2B["CHMP2B"]
    C9ORF72 -->|"associated_with"| CHMP2B
    style C9ORF72 fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style DEMENTIA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style TDP_43 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style STAU1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ATP13A2 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style SMCR8 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Schizophrenia fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ALS fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style RICTOR fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CHMP2B fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0