BLNK

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolBLNK
NameB cell linker
Typeprotein-coding
Sourcemygene

Summary

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which th

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