| Gene Symbol | ent-gene-224a2814 |
| Hippocampal CA1-CA3 regions | GRIK1 is expressed in pyramidal neurons of CA1-CA3, where it contributes to synaptic integration and long-term potentiation (LTP) |
| Dentate gyrus | Both granule cells and hilar interneurons express GRIK1, regulating dentate gate function and pattern separation |
| Subiculum | GRIK1-positive neurons in the subiculum project to cortical and subcortical targets |
| Layer 2/3 pyramidal neurons | Contributing to intracortical connectivity |
| Layer 5 pyramidal neurons | Major output neurons to subcortical structures |
| Cortical interneurons | Specific subtypes express GRIK1, modulating cortical inhibition |
| Cerebellar granule cells | The most abundant excitatory neurons in the brain, receiving mossy fiber inputs |
| Purkinje cells | Express GRIK1 at lower levels, modulating cerebellar output |
| Deep cerebellar nuclei | Projection neurons integrating cerebellar information |
| Amygdala | Modulating emotional processing and fear conditioning |
| Thalamus | Sensory relay nuclei show GRIK1 expression |
| Basal ganglia | Striatal medium spiny neurons and GABAergic interneurons |
| Extracellular N-terminal domain (ATD) | Involved in subunit assembly and ligand binding |
| Ligand-binding domain (LBD) | Binds glutamate and kainate with high affinity |
| Transmembrane domains (M1-M4) | Form the ion channel pore |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!