Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about cte: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
flowchart TD
CTE["CTE"] -->|"phosphorylates"| TAU["TAU"]
TAU["TAU"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
TAU["TAU"] -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
TAU["TAU"] -->|"associated with"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
TAU["TAU"] -->|"associated with"| TAUOPATHY["TAUOPATHY"]
style CTE fill:#006494,stroke:#333,color:#e0e0e0
style TAU fill:#4a1a6b,stroke:#333,color:#e0e0e0
style NEURODEGENERATION fill:#5d2900,stroke:#333,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#333,color:#e0e0e0
style TAUOPATHY fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TAU | phosphorylates | entity | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Smartphone-Detected Motor Variability Correction | 0.563 | neurodegeneration | Digital biomarkers and AI-driven early d |
| APOE4 Isoform Correction via Lipidation Enhancement as CTE R | 0.552 | neurodegeneration | What genetic risk factors predispose ind |
| Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro | 0.488 | neurodegeneration | What are the mechanisms by which gut mic |
| TFAM overexpression creates mitochondrial donor-recipient gr | 0.474 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Bacterial Enzyme-Mediated Dopamine Precursor Synthesis | 0.364 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.552
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.604
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673] | Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge | Autophagy | 2024 | 1 |
| TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142] | Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha | Nat Cell Biol | 2024 | 1 |
| Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090] | Lin MM, Liu N, Qin ZH, Wang Y | Acta Pharmacol Sin | 2022 | 1 |
| Atremorine in Parkinson's disease: From dopaminergic neuroprotection to pharmaco [PMID:34106485] | Cacabelos R, Carrera I, Martínez O, Alej | Med Res Rev | 2021 | 1 |
| Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785] | Zhao M, Wang Y, Li L, Liu S, Wang C, Yua | Theranostics | 2021 | 1 |
| Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045] | Filograna R, Mennuni M, Alsina D, Larsso | FEBS Lett | 2021 | 1 |
| Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434] | Li C, Zhang Y, Liu J, Kang R, Klionsky D | Autophagy | 2021 | 1 |
| Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation [PMID:31120439] | Luo Z, Ahlers-Dannen KE, Spicer MM, Yang | JCI Insight | 2019 | 1 |
| Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant [PMID:31873106] | Yedlapudi D, Xu L, Luo D, Marsh GB, Todi | Sci Rep | 2019 | 1 |
| A systematic review and integrative approach to decode the common molecular link [PMID:28927418] | Guin D, Mishra MK, Talwar P, Rawat C, Ku | BMC Med Genomics | 2017 | 1 |
| The role of genetic factors in the occurrence of levodopa-induced motor complica [PMID:40632937] | ["Radojevi\u0107 B", "Milovanovi\u0107 A | Neurological research | 2026 | 0 |
| Reliability and Discriminant Ability of an Instrumented Timed Up and Go Test in [PMID:41921127] | ["Giardini M", "Arcolin I", "Arcobelli V | JMIR rehabilitation and assist | 2026 | 0 |
| Gene therapy for Parkinson's disease: current landscape, translational challenge [PMID:41837837] | Evola V, Parmar MS | Expert review of neurotherapeu | 2026 | 0 |
| 7-ketocholesterol as a theranostic target: potential applications and future per [PMID:41936993] | Lizard G, Sassi K, Mackrill JJ, Ghzaiel | Chem Phys Lipids | 2026 | 0 |
| Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836] | Vinutha AS, Akshay S, Sree Agash SG, Cha | Archives of microbiology | 2026 | 0 |
| The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877] | Gurnani B, Jain N | The Journal of biological chem | 2026 | 0 |
| Butyrate extends health and lifespan in mice with mitochondrial deficiency. [PMID:41826362] | ["Gaband\u00e9-Rodr\u00edguez E", "G\u00 | Nature communications | 2026 | 0 |
| Vav-iCre-Mediated Deletion of TFAM Is Not Recoverable and Is Consistent with Emb [PMID:41898789] | ["Ghosh R", "Shakur E", "Yousefzadeh M"] | Genes | 2026 | 0 |
| NRIP1 co-activates nuclear translocated FOXO3 to upregulate TFAM expression and [PMID:41888517] | ["Zha Y", "Huang H", "Liu Y", "Wan M", " | Cell death discovery | 2026 | 0 |
| miR-137-5p-Loaded Milk-Derived Small Extracellular Vesicles Modulate Oxidative S [PMID:41754992] | ["G\u00f6n\u00fcll\u00fc S", "Ayd\u0131n | Pharmaceutics | 2026 | 0 |