Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about alzheimers-disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Diseases | Alzheimer's disease, Parkinson's disease, ALS, FTD, Huntington's disease, PSP, MSA |
| Brain regions | substantia nigra, striatum, motor cortex, hippocampus, frontal cortex |
| Cell types | dopaminergic neurons, astrocytes, microglia, motor neurons, oligodendrocytes |
| Proteins/Genes | tau, alpha-synuclein, TDP-43, SNCA, GBA, LRRK2, C9orf72, HTT |
| Therapeutics | gene therapy, ASOs, CRISPR gene editing, deep brain stimulation |
| Pathways | complement system, neurotrophic signaling, cell death pathways |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
alzheimers_disease["alzheimers-disease"]
APOE["APOE"]
alzheimers_disease -->|"references"| APOE
GFAP["GFAP"]
alzheimers_disease -->|"references"| GFAP
TREM2["TREM2"]
alzheimers_disease -->|"references"| TREM2
style alzheimers_disease fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||