Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEURODEGENERATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Neurodegeneration refers to the progressive structural and functional loss of neurons. It is the hallmark of diseases including Alzheimer's, Parkinson's, ALS, Huntington's, and frontotemporal dementia. Shared mechanisms across neurodegenerative diseases include proteostasis failure, mitochondrial dysfunction, oxidative stress, synaptic loss, and neuroinflammation. These convergent pathways are key targets for therapeutic intervention.
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"associated with"| NEURON["NEURON"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"associated with"| OLIGODENDROCYTE["OLIGODENDROCYTE"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"associated with"| Neurodegeneration["Neurodegeneration"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"associated with"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"associated with"| Alzheimer["Alzheimer"]
TAU["TAU"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
APOPTOSIS["APOPTOSIS"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
MS["MS"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
FERROPTOSIS_2["FERROPTOSIS"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
end
subgraph Signaling["Signaling"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| Als["Als"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| ALZHEIMER_S_DISEASE_1["ALZHEIMER'S DISEASE"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| P62["P62"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| FERROPTOSIS["FERROPTOSIS"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
TAU_3["TAU"] -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
end
style NEURODEGENERATION fill:#5d4400,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OLIGODENDROCYTE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style FERROPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TAU fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOPTOSIS fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MS fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEUROINFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style FERROPTOSIS_2 fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TAU_3 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| PARKINSON'S DISEASE | causes | disease | 1.00 |
| NEURON | associated_with | gene | 1.00 |
| OLIGODENDROCYTE | associated_with | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| FERROPTOSIS | activates | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | activates | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| ALS | activates | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | therapeutic_target | gene | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Huntington | therapeutic_target | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | therapeutic_target | disease | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| PI3K | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| Huntington | activates | disease | 1.00 |
| Neurodegeneration | inhibits | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| TAU | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| Tauopathy | activates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Mitophagy | inhibits | pathway | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Neurodegeneration | contributes_to | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FERROPTOSIS | associated_with | phenotype | 1.00 |
| APOE | associated_with | gene | 1.00 |
| TREM2 | associated_with | gene | 1.00 |
| C9ORF72 | causes | gene | 1.00 |
| CASP3 | associated_with | gene | 1.00 |
| MAPT | associated_with | gene | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| ALS | activates | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| ALS | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| AMYLOID | associated_with | gene | 1.00 |
| AMPK | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| NEUROTOXICITY | activates | gene | 1.00 |
| JUN | associated_with | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| BDNF | associated_with | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| ASTROCYTES | associated_with | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| APOPTOSIS | implicated_in | gene | 1.00 |
| NEUROTOXICITY | therapeutic_target | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| TAU | associated_with | protein | 1.00 |
| APOPTOSIS | causes | phenotype | 1.00 |
| MS | causes | disease | 1.00 |
| NEUROINFLAMMATION | activates | phenotype | 1.00 |
| TAU | activates | protein | 1.00 |
| CANCER | regulates | gene | 1.00 |
| HUNTINGTON | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| NEUROTOXICITY | associated_with | gene | 1.00 |
| AUTOPHAGY | implicated_in | gene | 1.00 |
| MITOPHAGY | inhibits | gene | 1.00 |
| BRAIN INJURY | activates | gene | 1.00 |
| MITOPHAGY | regulates | gene | 1.00 |
| MITOPHAGY | therapeutic_target | gene | 1.00 |
| MICROGLIA | regulates | gene | 0.98 |
| LCPUFA | involved_in | compound | 0.95 |
| STING | mediates | entity | 0.95 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.780
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.562
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Mapping the immune landscape of PCa: From tumor microenvironment to therapeutics [PMID:41956336] | Huang S, Ou Y, Zhuang W, Huang J, Wang B | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412] | Villani A, Wittmann J, Wyss T, Mallona I | Commun Biol | 2026 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | Int J Mol Sci | 2025 | 0 |
| Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impair [PMID:33584302] | Huang S, Liu H, Lin Y, Liu M, Li Y et al | Front Pharmacol | 2020 | 0 |
| Inflammasome and toll-like receptor signaling in human monocytes after successfu [PMID:27260481] | Asmussen A, Fink K, Busch HJ, Helbing T, | Crit Care | 2016 | 0 |
| Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is respon [PMID:24879148] | Guo W, Sun Y, Liu W, Wu X, Guo L et al. | Autophagy | 2014 | 0 |
| Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376] | Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa | 1993 | 0 |