psen1-mutations

Understanding Entity Pages

This page aggregates everything SciDEX knows about psen1-mutations: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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flowchart TD
    N0["PSEN1 mutations"]
    N1["Inflammatory Response"]
    N0 -->|"exacerbates"| N1
    N2["JAK-STAT Signalling"]
    N0 -->|"associated with"| N2
    N3["IFNAR2"]
    N0 -.->|"downregulates"| N3
    N4["STAT2 phosphorylation"]
    N0 -->|"associated with"| N4

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N2 pathway