tardbp-mutations-als

Understanding Entity Pages

This page aggregates everything SciDEX knows about tardbp-mutations-als: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    TARDBP["TARDBP"]
    Ubiquitin["Ubiquitin"]
    TARDBP -->|"degrades"| Ubiquitin
    Complement["Complement"]
    TARDBP -->|"inhibits"| Complement
    SNCA["SNCA"]
    TARDBP -->|"associated_with"| SNCA
    MCOLN1["MCOLN1"]
    TARDBP -->|"activates"| MCOLN1
    SOD1["SOD1"]
    TARDBP -->|"co_expressed_with"| SOD1
    Inflammation["Inflammation"]
    TARDBP -->|"therapeutic_target"| Inflammation
    UNFOLDED_PROTEIN_RESPONSE["UNFOLDED PROTEIN RESPONSE"]
    TARDBP -->|"co_discussed"| UNFOLDED_PROTEIN_RESPONSE
    ALS["ALS"]
    TARDBP -->|"interacts_with"| ALS
    ATG["ATG"]
    TARDBP -->|"activates"| ATG
    TARDBP -->|"inhibits"| ALS
    Motor_Neuron_Loss["Motor Neuron Loss"]
    TARDBP -->|"causes"| Motor_Neuron_Loss
    Tdp_43_Proteinopathy["Tdp-43 Proteinopathy"]
    TARDBP -->|"involved_in"| Tdp_43_Proteinopathy
    style TARDBP fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style Ubiquitin fill:#4a1a6b,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Complement fill:#1b5e20,stroke:#333,stroke-width:1px,color:#e0e0e0
    style SNCA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MCOLN1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style SOD1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style UNFOLDED_PROTEIN_RESPONSE fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ALS fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ATG fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Motor_Neuron_Loss fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Tdp_43_Proteinopathy fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0