Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about endothelia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| cerebral_blood_flow_regulation | involved_in | unknown | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SLC7A11 System Activation Restores Cystine Uptake and GSH Sy | 0.812 | neurodegeneration | View |
| Synthetic Biology BBB Endothelial Cell Reprogramming | 0.727 | neurodegeneration | Blood-brain barrier transport mechanisms |
| Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat | 0.705 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Endothelial NRF2 Activation as a Master Switch for Post-CA B | 0.689 | neurodegeneration | View |
| Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repres | 0.645 | - | What blood-brain barrier permeability ch |
| Circulating Endothelial Microvesicles Expressing Degraded Cl | 0.640 | - | What blood-brain barrier permeability ch |
| Circulating Endothelial Microparticles Expressing Activated | 0.565 | - | What blood-brain barrier permeability ch |
| endothelial transcytosis defines the therapeutic window for: | 0.357 | neurodegeneration | Blood-brain barrier permeability changes |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| s:** - Compare uptake with/without magnetic particles using tight junc | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $120,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Blood-Based Biomarker Panel for Early AD Detection | clinical | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $220,000 |
| Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $130,000 |
| Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Vascular Contribution to Alzheimer's Disease — Beyond Amyloid | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Vascular Contributions to Alzheimer Disease and Mixed Pathology | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] | Fei Y, Huang X, Ning F, Qian T, Cui J, W | Biomed Pharmacother | 2024 | 1 |
| Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286] | Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei | Respir Res | 2021 | 1 |
| The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825] | Uchimido R, Schmidt EP, Shapiro NI | Crit Care | 2019 | 1 |
| Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009] | Yıldırım MA, Korkmaz S, Çelik HHA, Büyük | Cutis | 2026 | 0 |
| CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134] | Odendaal J, Fishwick K, Correia GDS, Lee | Human reproduction (Oxford, En | 2026 | 0 |
| [Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411] | Yin XY, Zhao ZH, Wang Y, Cai N, Chen S | Zhongguo dang dai er ke za zhi | 2026 | 0 |
| Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425] | Alagarasu K, Gurav YK, Pulinchani A, Bac | Journal of medical virology | 2026 | 0 |
| Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595] | Mathis S, Putzer G, Gasteiger L, Staier | Transplant international : off | 2026 | 0 |
| Crossing the blood-brain barrier: emerging therapeutic strategies for neurologic [PMID:39862873] | Pedder JH, Sonabend AM, Cearns MD | Lancet Neurol | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Diseas [PMID:35008731] | Unknown | International journal of molec | 2022 | 0 |
| Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Diseas [PMID:35008731] | Pluta, Januszewski, Czuczwar | International journal of molec | 2022 | 0 |
| Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic bas [PMID:36577758] | Gharbi Severine Isabelle; Pelletier Laur | NPJ breast cancer | 2022 | 0 |
| The biology of beauty sleep. [PMID:35256810] | Jordan A Anderson; Jenny Tung | Nature ecology & evolution | 2022 | 0 |
| Cathepsin S is a novel target for age-related dry eye. [PMID:34910926] | ["Yu Z", "Li J", "Govindarajan G", "Hamm | Experimental eye research | 2022 | 0 |
| Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effe [PMID:33544062] | ["Rodr\u00edguez M", "Pintado C", "Torri | Nutritional neuroscience | 2022 | 0 |
| Strategies for delivering therapeutics across the blood-brain barrier. [PMID:33649582] | Terstappen GC, Meyer AH, Bell RD | Nat Rev Drug Discov | 2021 | 0 |
| Strategies for delivering therapeutics across the blood-brain barrier. [PMID:33649582] | ["Terstappen GC", "Meyer AH", "Bell RD"] | Nat Rev Drug Discov | 2021 | 0 |
| Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867] | ["Yu K", "Niu X", "Krook-Magnuson E", "H | Nature communications | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning endothelia in their description or question text
Score: 0.640 · unknown disease · 2026-04-26
Endothelial cells shed microvesicles (EMVs) during activation or injury. EMVs from degenerating brain endothelium carry
Score: 0.565 · unknown disease · 2026-04-26
Cerebral microvascular endothelial cells shed submicron microparticles (EMPs) upon activation or apoptosis. EMPs carry s
Score: 0.357 · neurodegeneration · 2026-04-26
The same signal may be beneficial early and damaging late. Testing endothelial transcytosis with pericyte-protective dos