Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about gba-gene-therapy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | gba-gene-therapy |
Knowledge base pages for this entity
flowchart TD
gba_gene_therapy["gba-gene-therapy"] -->|"references"| SNCA["SNCA"]
gba_gene_therapy["gba-gene-therapy"] -->|"references"| TFEB["TFEB"]
SNCA["SNCA"] -->|"encodes"| ALPHA_SYNUCLEIN["ALPHA_SYNUCLEIN"]
SNCA["SNCA"] -->|"associated with"| Dementia["Dementia"]
SNCA["SNCA"] -->|"implicated in"| dementia_with_Lewy_bodies["dementia with Lewy bodies"]
SNCA["SNCA"] -->|"encodes"| __SYNUCLEIN["Alpha-SYNUCLEIN"]
TFEB["TFEB"] -->|"activates"| GENES["GENES"]
TFEB["TFEB"] -->|"activates"| Autophagy["Autophagy"]
TFEB["TFEB"] -->|"activates"| Als["Als"]
TFEB["TFEB"] -->|"regulates"| Als["Als"]
style gba_gene_therapy fill:#6d3000,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
style SNCA fill:#4a1a6b,stroke:#333,color:#e0e0e0
style TFEB fill:#4a1a6b,stroke:#333,color:#e0e0e0
style ALPHA_SYNUCLEIN fill:#006494,stroke:#333,color:#e0e0e0
style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
style dementia_with_Lewy_bodies fill:#ef5350,stroke:#333,color:#e0e0e0
style __SYNUCLEIN fill:#006494,stroke:#333,color:#e0e0e0
style GENES fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning gba-gene-therapy in their description or question text
No additional research found