Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lysyl_oxidase: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| collagen_crosslinking | catalyzes | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LOX | encodes | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Matrix Stiffness Normalization via Targeted Lysyl Oxidase In | 0.515 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Evolutionary conservation and Immunoregulatory function of LOXL3 gene in lamprey [PMID:40816690] | Pang Y, Yan Z, Gao Y, Li D, Zhao L, Ma G | Fish Shellfish Immunol | 2025 | 1 |
| Machine learning-based in-silico analysis identifies signatures of lysyl oxidase [PMID:40186284] | Xu Q, Ma L, Streuer A, Altrock E, Schmit | Cell Commun Signal | 2025 | 1 |
| Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked [PMID:40465757] | ["Ventura-Antunes L", "Nackenoff A", "Ro | Alzheimer's & dementia : the j | 2025 | 0 |
| LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic [PMID:39260063] | ["Jiang D", "Zhao J", "Zheng J", "Zhao Y | Redox biology | 2024 | 0 |
| Cardiomyocyte senescence and the potential therapeutic role of senolytics in the [PMID:39119147] | ["Zhai P", "Sadoshima J"] | The journal of cardiovascular | 2024 | 0 |
| Effects of Age, Sex, and Extracellular Matrix Integrity on Aortic Dilatation and [PMID:37470181] | ["Weiss D", "Rego B", "Cavinato C", "Li | Arteriosclerosis, thrombosis, | 2023 | 0 |
| Single-cell analysis reveals lysyl oxidase (Lox) [PMID:36706988] | ["Li H", "Zhu X", "Cao X", "Lu Y", "Zhou | Journal of advanced research | 2023 | 0 |
| Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via [PMID:37328872] | ["Cheng F", "Yang F", "Wang Y", "Zhou J" | Journal of nanobiotechnology | 2023 | 0 |
| Influence of Substrate Stiffness on Barrier Function in an iPSC-Derived [PMID:35096185] | ["Bosworth A", "Kim H", "O'Grady K", "Ri | Cellular and molecular bioengi | 2022 | 0 |
| BIN1 is a key regulator of proinflammatory and neurodegeneration-related activat [PMID:35526014] | Sudwarts A, Ramesha S, Gao T | Mol Neurodegener | 2022 | 0 |
| Correlation of Matrisome-Associatted Gene Expressions with LOX Family Members in [PMID:36076905] | ["Laurentino T", "Soares R", "Marie S", | International journal of molec | 2022 | 0 |
| Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic p [PMID:29278308] | ["Gao L", "Wu C", "Fu F", "You X", "Ma X | Journal of cellular and molecu | 2018 | 0 |
| Targeting lysyl oxidase reduces peritoneal fibrosis. [PMID:28800626] | ["Harlow C", "Wu X", "van Deemter M", "G | PloS one | 2017 | 0 |
| LOX-1 and neurodegeneration. [PMID:24929221] | Liu J | Neurosci Lett | 2014 | 0 |
| Gene-environment interaction models to unmask susceptibility mechanisms in Parki [PMID:24430802] | ["Chou V", "Ko N", "Holman T", "Manning- | Journal of visualized experime | 2014 | 0 |
| Developmental vasculotoxicity associated with inhibition of semicarbazide-sensit [PMID:10079209] | ["Langford S", "Trent M", "Balakumaran A | Toxicology and applied pharmac | 1999 | 0 |
| Spontaneous rupture of the internal elastic lamina in the rat: the manifestation [PMID:2575918] | ["Capdeville M", "Coutard M", "Osborne-P | Blood vessels | 1989 | 0 |