mapt-variants

Understanding Entity Pages

This page aggregates everything SciDEX knows about mapt-variants: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    MAPT["MAPT"]
    lysosome["lysosome"]
    MAPT -->|"activates"| lysosome
    Alzheimer["Alzheimer"]
    MAPT -->|"therapeutic_target"| Alzheimer
    LRP8["LRP8"]
    MAPT -->|"co_expressed_with"| LRP8
    JUN["JUN"]
    MAPT -->|"interacts_with"| JUN
    HSPE1["HSPE1"]
    MAPT -->|"expressed_in"| HSPE1
    MAPT -->|"transports"| LRP8
    OPTN["OPTN"]
    MAPT -->|"associated_with"| OPTN
    STMN1["STMN1"]
    MAPT -->|"expressed_in"| STMN1
    SQSTM1["SQSTM1"]
    MAPT -->|"activates"| SQSTM1
    BACE1["BACE1"]
    MAPT -->|"contributes_to"| BACE1
    ALS["ALS"]
    MAPT -->|"biomarker_for"| ALS
    LIPA["LIPA"]
    MAPT -->|"regulates"| LIPA
    style MAPT fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style lysosome fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style LRP8 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style JUN fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style HSPE1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style OPTN fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style STMN1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style SQSTM1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style BACE1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style LIPA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0