Centrosome

Understanding Entity Pages

This page aggregates everything SciDEX knows about Centrosome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

The centrosome is the major microtubule-organizing center (MTOC) in animal cells, playing critical roles in cell division, intracellular transport, and cellular polarity. In neurons, the centrosome is active during development but becomes largely inert in mature neurons, which rely on alternative mi

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graph TD
    A["Upstream trigger"] --> B["Centrosome"]
    B --> C["Molecular cascade"]
    C --> D["Cellular dysfunction"]
    D --> E["Neuronal death"]
    B --> F["Inflammatory response"]
    F --> D
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    class B mechanism
    class E disease