Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about jnk-p38-mapk-parkinsons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways are central mediators of cellular stress responses in Parkinson's disease. These kinases play critical roles in dopaminergic neuron survival, neuroinflammation, and protein aggregation.
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Knowledge base pages for this entity
graph TD
A["Upstream trigger"] --> B["jnk p38 mapk parkinsons"]
B --> C["Molecular cascade"]
C --> D["Cellular dysfunction"]
D --> E["Neuronal death"]
B --> F["Inflammatory response"]
F --> D
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
class B mechanism
class E disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity