mechanism 1,315 words KG: ent-gene-dab15615
Contents

Sigma-1 Receptor (SIGMAR1) Signaling in Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-dab15615
Subcellular LocalizationER-mitochondria contact sites (mitochondria-associated membranes, MAMs) that regulates calcium homeostasis, mitochondria
NeurosteroidsPregnenolone, DHEA
SphingolipidsCeramide
PRE-084Selective sigma-1 agonist
SA-4503 (Cutamesine)Agonist with neuroprotective effects
DextromethorphanFDA-approved cough suppressant with sigma-1 agonist activity
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (55)

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Synthetic Biology BBB Endothelial Cell Reprogramming
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Related Analyses (30)

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neurodegeneration · archived
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Related Experiments (30)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-dab15615 data_in benchmark_ot_ad_answer_key:SIGMAR1
benchmark_ot_ad_answer_key:SIGMAR1 data_in ent-gene-dab15615

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